Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors.
نویسندگان
چکیده
The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.
منابع مشابه
The effect on the lanthanide luminescence of structurally simple Eu(III) cyclen complexes upon deprotonation of metal bound water molecules and amide based pendant arms.
A series of substituted 1,4,7,10-tetraazacylcododecane ligands 1-4, possessing sensitizing nitrobenzene or naphthalene antennae, as one of the amide pendant arms, and their complexes with europium(III) were synthesised. The protonation constants and the metal ion stability constants of two of these ligands were determined by potentiometric titration. The pK(a) of the water molecules coordinated...
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The design and synthesis of dinuclear-lanthanide complexes possessing triazole-based bridges, formed by using copper catalysed 1,3-cycloaddition reactions between heptadentate alkyne functionalised cyclen europium or terbium complexes and di-azides (CuAAC reactions), are described. While this click reaction worked well for the formation of the homo-Eu(III) and Tb(III) bis-tri-arm cyclen N,N-dim...
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Lanthanide(III) chloro complexes of 4[N-(4’-hydroxy-3’-methoxybenzalidene) amino] antipyrine semicarbazone (HMBAAPS) (I) and 4[N-(3’,4’,5’-trimethoxybenzalidene) amino] antipyrine semicarbazone (TMBAAPS) (II) with the general composition LnCl3.2L (Ln = La, Pr, Nd, Sm, Gd, Tb, Dy or Ho; L = HMBAAPS or TMBAAPS) are reported. All the complexes were synthesized in ethanolic medium and refluxed the ...
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For elucidating the mechanism of the general acid/base catalysis of the hydrolysis of RNA phosphodiester bonds, a number of cleaving agents having two cyclen moieties tethered to a 1,3,5-triazine core have been prepared and their ability to bind and cleave uridylyl-3',5'-uridine (UpU) studied over a wide pH range. Around neutral pH, the cleaving agents form a highly stable ternary complex with ...
متن کاملStrategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.
The synthesis and (19)F NMR spectroscopic properties are reported for three series of CF(3)-labelled lanthanide(III) complexes, based on mono- and diamide cyclen ligands. Analyses of variable temperature, pH and field (19)F, (17)O and (1)H NMR spectroscopic experiments are reported and the merits of a triphosphinate mono-amide complex defined by virtue of its favourable isomer distribution and ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 36 شماره
صفحات -
تاریخ انتشار 2006